Streamline your purification workflow

The Prodigy™ is a unique preparative HPLC with a fully integrated heating system to access elevated temperatures for improved performance with peptide purification. Perform chromatographic methods from the elevated temperature analytical scale directly at the preparative scale.

Fully integrated heating system
Reduced fractions with built-in focused gradient methods
UV-directed fraction collection
Intuitive touchscreen software interface
Flow rates up to 250 mL/min

Integrated Heating System

Heating at a uniform temperature for the best performance.

Traditional elevated temperature preparative chromatography approaches often focus on column heating only. While this can reduce the system backpressure, it introduces significant band broadening due to a mismatch of temperature between the column wall and the cold incoming mobile phase.

The Prodigy heats both the mobile phase and the column to a uniform temperature, enabling high efficiency chromatography for temperatures up to 80 °C.

Elevated Temperature Chromatography

Excellent separation of hydrophobic peptides.

Elevated temperatures increase the solubility of hydrophobic peptides, improving peak shape and resolution. This results in higher fraction purities and recoveries, while minimizing the number of fractions.

Chromatographic Selectivity

Resolve more impurities.

Temperature is an important parameter that can affect chromatographic selectivity. With the Prodigy, you can maximize your ability to resolve closely eluting impurities.

Workflow Solution

No more ambient temperature scouting runs.

Conventional ambient temperature purification workflows often require additional scouting runs. With the Prodigy, elevated temperature analytical runs can be performed directly at the preparative scale.

Productivity

Run the fastest, most optimized methods.

The use of elevated temperatures results in improved mass transfer kinetics and reduced system backpressure. This enables much higher flow rates and shorter run times.

The built-in focused gradient calculator makes it easy to create optimized focused gradients, minimizing run time while maximizing resolution around the target peak.

Intuitive Software

User-friendly software, scientist centered design.

The touchscreen software interface enables the fast, easy, and efficient operation of the system.

Step 1. Enter the Parameters

Open the Focused Gradient Calculator and enter the parameters from your analytical run.

Step 2. Convert the Analytical run into a Preparative Run

The Focused Gradient Calculator automatically converts your analytical run into a preparative run using an optimized focused gradient.

Step 3. Start the Run

Select a method and enter the optimized parameters, then touch the “Start” button to begin.

Configurations

Get a Prodigy that fits your needs.

Standard Configuration

Flow rates up to 50 mL/min
Columns up to 30 mm in diameter (19/21.2 mm ideal)
Purify up to 500 mg of material

High Flow Configuration

Flow rates up to 250 mL/min
Columns up to 50 mm in diameter
Purify up to 1.5 grams of material

Column Options

Bundle Waters columns with your Prodigy.

If you need columns, we can include industry leading BEH (ethylene bridged hybrid) columns from Waters™ with your Prodigy.1

BEH Technology™ ensures maximum column performance and longer column lifetimes under all chromatographic conditions and including elevated temperature.

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